Description
Quick Facts
The primary mechanism of action for 5-Amino-1-MQ is its direct and selective inhibition of the NNMT enzyme. By inhibiting NNMT, 5-Amino-1-MQ leads to:
- Increased Cellular NAD+ Levels: NNMT typically metabolizes nicotinamide, a precursor to NAD+. By blocking this metabolic step, 5-Amino-1-MQ helps to preserve and increase the cellular levels of nicotinamide and, consequently, NAD+ (Nicotinamide Adenine Dinucleotide). NAD+ is a crucial coenzyme involved in countless metabolic processes, including energy production, DNA repair, and sirtuin activation (which are linked to longevity and metabolic health).
- Enhanced Metabolic Activity in Adipocytes: In adipose tissue, NNMT activity has been linked to increased fat accumulation and reduced energy expenditure. By inhibiting NNMT, 5-Amino-1-MQ is hypothesized to shift adipocytes towards a more metabolically active state, promoting fat breakdown (lipolysis) and reducing fat storage (lipogenesis).
- Improved Energy Expenditure: Preclinical studies suggest that NNMT inhibition can lead to an increase in overall energy expenditure, which can contribute to fat loss and improved metabolic health.
- Obesity and Weight Management: A major area of research for its potential to reduce fat mass, particularly visceral fat, and improve body composition without directly affecting appetite. Its mechanism of action offers a novel approach to obesity treatment.
- Metabolic Syndrome: Investigated for its ability to improve various components of metabolic syndrome, including dyslipidemia (abnormal blood lipid levels) and insulin sensitivity, by favorably altering fat metabolism and energy expenditure.
- Non-Alcoholic Fatty Liver Disease (NAFLD): Explored for its potential to reduce hepatic steatosis (fatty liver) by promoting fat breakdown and reducing fat accumulation in the liver.
- Mitochondrial Function: Given its impact on NAD+ levels, research may extend to its influence on mitochondrial health and efficiency, which are central to various metabolic processes.
- Cancer Research: NNMT is often overexpressed in certain cancers, and its inhibition with compounds like 5-Amino-1-MQ is an emerging area of anti-cancer research.
Why Choose Peptide Chains for 5-Amino-1-MQ?
Peptide Chains provides high-purity 5-Amino-1-MQ in bulk API quantities, essential for rigorous metabolic research, pharmaceutical development, and specialized formulations. Our 5-Amino-1-MQ is meticulously sourced and supplied, ensuring optimal integrity, purity (typically ≥98%), and consistency for your precise experimental protocols. We are committed to stringent quality control, including comprehensive analytical testing, to guarantee the exceptional purity and batch-to-batch reliability that is critical for reproducible results in studies focused on NNMT inhibition, targeted fat reduction, metabolic regulation, and the exploration of novel therapeutic strategies for obesity and related metabolic disorders.
