info@peptidechains.com – 16192 Coastal HWY Lewes, DE 19958

No products in the cart.

New Client Signup
Gonadorelin
Gonadorelin

Gonadorelin

Gonadorelin is a synthetic decapeptide that is chemically identical to the naturally occurring gonadotropin-releasing hormone (GnRH), produced by the hypothalamus. GnRH plays an absolutely central role in regulating the reproductive axis in all mammals. It acts as the master controller of gonadotropin secretion from the anterior pituitary gland, which in turn governs the function of the gonads (testes in males, ovaries in females). Administered in a pulsatile manner, Gonadorelin mimics the physiological release pattern of endogenous GnRH, making it an invaluable tool for both diagnostic and therapeutic research in reproductive endocrinology.

Submit an Inquiry
SKU: 167 Category:

Description

Quick Facts

Gonadorelin primarily exerts its effects by binding to and activating specific GnRH receptors located on the gonadotroph cells within the anterior pituitary gland. The response to Gonadorelin is highly dependent on its mode of administration:

 

  • Pulsatile Administration: When administered in a pulsatile fashion, mimicking the natural hypothalamic GnRH secretion, Gonadorelin stimulates the pituitary to synthesize and release both Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). These gonadotropins then travel to the gonads, where they stimulate the production of sex steroids (e.g., testosterone, estrogen) and support gametogenesis (sperm and egg development).
  • Continuous (Non-pulsatile) Administration: Conversely, continuous or excessively frequent administration of Gonadorelin leads to a desensitization and downregulation of GnRH receptors on the pituitary gonadotrophs. This results in an initial surge of LH and FSH, followed by a suppression of gonadotropin release and, consequently, a reduction in sex steroid production, effectively inducing a state of reversible hypogonadism.
  • Reproductive Endocrinology: Extensive research into its role in diagnosing and treating various reproductive disorders, including hypothalamic amenorrhea, delayed puberty, and infertility in both males and females.
  • Fertility Research: Used to induce ovulation in anovulatory women and to stimulate spermatogenesis in hypogonadal men. It is a critical component in assisted reproductive technologies (ART).
  • Puberty Induction: Investigated for its role in initiating puberty in individuals with GnRH deficiency.
  • Contraception Research: Continuous administration methods are explored for their potential as a form of reversible contraception by suppressing gonadotropin release.
  • Veterinary Reproductive Management: Widely used in veterinary medicine for reproductive synchronization and management in livestock and other animals.
  • Pituitary Function Assessment: Used as a diagnostic agent to assess the functional integrity of the pituitary-gonadal axis, differentiating between hypothalamic and pituitary causes of hypogonadism.

 

Why Choose Peptide Chains for Gonadorelin?

Peptide Chains provides high-purity Gonadorelin in bulk API quantities, essential for rigorous research, pharmaceutical development, and compounding applications in reproductive medicine. Our Gonadorelin is meticulously synthesized and supplied in a stable, lyophilized format, ensuring optimal integrity, purity (typically ≥98%), and ease of reconstitution for your precise experimental protocols. We are committed to stringent quality control, including comprehensive analytical testing, to guarantee the exceptional purity, potency, and batch-to-batch consistency that is critical for reliable and reproducible results in studies focused on fertility, reproductive hormone regulation, and the complex dynamics of the hypothalamic-pituitary-gonadal axis.

Additional information

Weight 0.05 lbs
Dimensions 10 × 15 × 5 in
Size

100g, 500g, 1kg

Related products

  • Thymosin-B4-(TB-500)

    Thymosin Beta-4 (Tβ4) is a naturally occurring, ubiquitous 43-amino acid peptide found in virtually all human and animal cells, with particularly high concentrations in tissues in

    Get Pricing This product has multiple variants. The options may be chosen on the product page
  • Semaglutide

    Semaglutide is a highly effective synthetic analog of glucagon-like peptide-1 (GLP-1), an incretin hormone naturally secreted by the gut in response to food intake. Designed for pr

    Get Pricing This product has multiple variants. The options may be chosen on the product page
  • SS-31

    SS-31, chemically known as D-Arg-Dmt-Lys-Phe-NH2 (where Dmt is dimethyltyrosine), is a novel and highly targeted mitochondrial-targeted peptide. It belongs to a class of peptides d

    Get Pricing This product has multiple variants. The options may be chosen on the product page
  • Ipamorelin

    Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) and a highly selective growth hormone secretagogue (GHS). Unlike some other growth hormone-releasing peptides

    Get Pricing This product has multiple variants. The options may be chosen on the product page
At Peptide Chains, we specialize in providing high-quality bulk Active Pharmaceutical Ingredients (APIs) and lyophilized compounds. We are dedicated to supplying the essential raw materials critical for innovation and development within the pharmaceutical, biotechnology, and compounding industries.

Quick Menu

Contact

© 2025 Peptide Chains, All Rights Reserved

Please note that all products offered on this website are intended solely for Research and Development purposes and must never be consumed by humans.

The U.S. Food and Drug Administration (FDA) has not evaluated the information on this site or the products we supply. Our products are not meant to diagnose, treat, cure, or prevent any medical condition.

Peptide Chains operates as a chemical supplier. We are not a compounding pharmacy or chemical compounding facility (under 503A) nor an outsourcing facility (under 503B) as defined by the Federal Food, Drug, and Cosmetic Act.