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Ibutamoren-MK-677
Ibutamoren-MK-677

Ibutamoren-MK-677

Ibutamoren, also widely known by its research code MK-677, is a potent, orally active, non-peptidic growth hormone secretagogue (GHS). Unlike exogenous growth hormone, Ibutamoren stimulates the body’s natural production and release of growth hormone (GH) and subsequently, insulin-like growth factor 1 (IGF-1). It belongs to a class of compounds known as ghrelin mimetics, as it mimics the action of the endogenous hormone ghrelin, which is primarily responsible for regulating hunger, energy balance, and GH secretion. Its orally bioavailable nature and prolonged half-life make it a convenient and effective tool for sustained elevation of GH and IGF-1 levels in research settings.

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Description

Quick Facts

Ibutamoren exerts its effects by selectively binding to and activating the ghrelin receptor (Growth Hormone Secretagogue Receptor 1a, GHSR1a), which is predominantly found in the brain (e.g., hypothalamus, pituitary gland) and other peripheral tissues. This binding triggers a signaling cascade that stimulates the somatotroph cells of the anterior pituitary to release growth hormone. Importantly, Ibutamoren achieves this without significantly affecting the levels of other hormones like cortisol, prolactin, or thyroid-stimulating hormone (TSH), thereby maintaining a relatively clean endocrine profile. The resulting increase in GH then drives the liver and other tissues to produce IGF-1, which mediates many of the anabolic and growth-promoting effects.

 

  • Growth Hormone Deficiency: Extensively researched for its potential to restore growth hormone and IGF-1 levels in individuals with GH deficiency, including children and older adults, to improve growth and overall health outcomes.
  • Muscle Wasting and Sarcopenia: Investigated for its ability to promote muscle growth (increase fat-free mass) and prevent muscle wasting associated with aging, chronic diseases (e.g., HIV/AIDS), or prolonged immobilization.
  • Bone Mineral Density: Studies explore its potential to increase bone formation markers and enhance bone mineral density, suggesting applications in osteoporosis research.
  • Body Composition Modulation: Research into its effects on overall body composition, including increasing lean mass and potentially reducing fat mass, through its anabolic pathways.
  • Metabolic Health: Explored for its influence on metabolism, though some studies note potential changes in glucose and insulin sensitivity that require careful consideration.
  • Neuroprotection and Cognitive Function: Emerging research investigates its potential neuroprotective effects and influence on cognitive processes, possibly linked to its impact on IGF-1 and other growth factors.
  • Sleep Quality: Some anecdotal and limited research suggest it may improve sleep architecture, potentially by influencing GH pulsatility which is linked to deep sleep stages.

 

Why Choose Peptide Chains for Ibutamoren (MK-677)?

Peptide Chains provides high-purity Ibutamoren (MK-677) in bulk API quantities, essential for rigorous scientific research and development. Our MK-677 is meticulously synthesized and supplied, ensuring optimal integrity, purity (typically ≥98%), and ease of formulation for your precise experimental protocols. We are committed to stringent quality control, including comprehensive analytical testing, to guarantee the exceptional purity, potency, and batch-to-batch consistency that is critical for reliable and reproducible results in studies focused on growth hormone modulation, muscle and bone health, metabolic regulation, and the broader fields of endocrinology and healthy aging.

Additional information

Weight 0.05 lbs
Dimensions 10 × 15 × 5 in
Size

100g, 500g, 1kg

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At Peptide Chains, we specialize in providing high-quality bulk Active Pharmaceutical Ingredients (APIs) and lyophilized compounds. We are dedicated to supplying the essential raw materials critical for innovation and development within the pharmaceutical, biotechnology, and compounding industries.

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Please note that all products offered on this website are intended solely for Research and Development purposes and must never be consumed by humans.

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