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Kisspeptin
Kisspeptin

Kisspeptin

Kisspeptin refers to a family of neuropeptides encoded by the KISS1 gene, with Kisspeptin-54 being the full-length, biologically active peptide (and Kisspeptin-10 as a key active fragment). These peptides are fundamental to the intricate regulation of the mammalian reproductive system. Discovered for its role in suppressing metastasis (hence its original name, metastin), Kisspeptin’s critical function in reproduction was subsequently identified. It acts as the primary gatekeeper for the onset of puberty and the maintenance of fertility throughout adulthood.

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Description

Quick Facts

The biological actions of Kisspeptin are mediated by its high-affinity binding to the G protein-coupled receptor, GPR54 (also known as Kiss1R), which is abundantly expressed on gonadotropin-releasing hormone (GnRH) neurons within the hypothalamus. Upon binding, Kisspeptin potently stimulates GnRH secretion in a pulsatile manner. GnRH, in turn, acts on the pituitary gland to release Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH), which then regulate gonadal function (testosterone and estrogen production, spermatogenesis, and ovulation). This hierarchical control positions Kisspeptin as the upstream activator of the hypothalamic-pituitary-gonadal (HPG) axis, integrating diverse signals from the body (e.g., metabolic status, stress) to govern reproductive processes.

 

  • Reproductive Endocrinology: Extensive research on its role in puberty, fertility disorders (e.g., hypothalamic amenorrhea, Kallmann syndrome, PCOS), and assisted reproductive technologies (ART).
  • Neuroendocrinology: Studies investigating the neural circuits and feedback loops that regulate GnRH neuron activity, and how Kisspeptin integrates metabolic and environmental cues to modulate reproduction.
  • Contraception & Fertility Management: Exploration of Kisspeptin and its antagonists as potential targets for novel fertility control strategies.
  • Gonadal Function: Used as a tool to investigate the direct and indirect effects of HPG axis activation on testicular and ovarian function.
  • Cancer Research: Continuing studies on its original identified role as a metastasis suppressor, particularly in melanoma and breast cancer.

 

Why Choose Peptide Chains for Kisspeptin?

Peptide Chains provides high-purity Kisspeptin (general, including Kisspeptin-54 if applicable) in bulk API quantities, essential for comprehensive and nuanced research into reproductive biology and neuroendocrinology. Our Kisspeptin is supplied in a stable, lyophilized format, ensuring optimal integrity and ease of handling for your precise experimental protocols. We maintain rigorous quality control standards, including detailed analytical verification, to guarantee the exceptional purity, potency, and batch-to-batch consistency vital for robust and reproducible results in studies focused on the fundamental regulation of the HPG axis and its broader physiological implications.

Additional information

Weight 0.05 lbs
Dimensions 10 × 15 × 5 in
Size

100g, 500g, 1kg

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At Peptide Chains, we specialize in providing high-quality bulk Active Pharmaceutical Ingredients (APIs) and lyophilized compounds. We are dedicated to supplying the essential raw materials critical for innovation and development within the pharmaceutical, biotechnology, and compounding industries.

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