Description
Quick Facts
KPV’s anti-inflammatory and antimicrobial effects are primarily mediated through its interaction with key cellular pathways, independent of broader melanocortin receptor activation that is characteristic of the full α-MSH molecule. Its mechanisms are believed to involve:
- NF-$\kappa$B Pathway Inhibition: KPV has been shown to directly inhibit the activation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-$\kappa$B) pathway. NF-$\kappa$B is a master regulator of inflammatory responses, and its inhibition leads to reduced production of pro-inflammatory cytokines such as TNF-α (Tumor Necrosis Factor alpha), IL-1$\beta$ (Interleukin-1 beta), and IL-6 (Interleukin-6).
- MAPK Pathway Modulation: It can also modulate components of the mitogen-activated protein kinase (MAPK) signaling pathways, further contributing to its anti-inflammatory effects.
- Direct Antimicrobial Activity: KPV exhibits direct antimicrobial properties against a range of bacteria, fungi, and potentially viruses. This action is thought to involve disruption of microbial membranes or interference with their metabolic processes. Its positively charged lysine residue and hydrophobic proline-valine sequence contribute to this activity, allowing it to penetrate and destabilize microbial structures.
- Cellular Apoptosis Regulation: In certain contexts, KPV has been shown to influence apoptosis (programmed cell death), which can be relevant in controlling immune cell proliferation during inflammation.
- Inflammatory Skin Conditions: Extensively investigated for its topical application in inflammatory dermatological conditions such as psoriasis, eczema, and dermatitis, due to its ability to reduce inflammation and promote healing.
- Gastrointestinal Inflammation: Research into its potential for treating inflammatory bowel diseases (IBD) like Crohn’s disease and ulcerative colitis, by mitigating gut inflammation.
- Ocular Inflammation: Explored for its use in inflammatory eye conditions, such as dry eye syndrome or uveitis.
- Antimicrobial Therapies: Research on its direct antimicrobial properties against various pathogens, offering potential for novel treatments for infections, including those resistant to conventional antibiotics.
- Wound Healing: Its anti-inflammatory and antimicrobial actions contribute to improved wound healing outcomes by reducing infection risk and excessive inflammation.
- Oral Health: Some studies investigate its use in conditions like gingivitis and periodontitis due to its localized anti-inflammatory and antimicrobial effects.
Why Choose Peptide Chains for KPV?
Peptide Chains provides high-purity KPV in bulk API quantities, essential for rigorous scientific research, pharmaceutical development, and specialized formulations. Our KPV is meticulously synthesized and supplied in a stable, lyophilized format, ensuring optimal integrity, purity (typically ≥98%), and ease of reconstitution for your precise experimental protocols. We are committed to stringent quality control, including comprehensive analytical testing, to guarantee the exceptional purity, potency, and batch-to-batch consistency that is critical for reliable and reproducible results in studies focused on inflammation modulation, antimicrobial strategies, dermatological treatments, and gut health.
