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MOTS-C
MOTS-C

MOTS-C

MOTS-c is a fascinating and relatively newly discovered peptide, unique in that it is encoded by a small open reading frame within the mitochondrial 12S ribosomal RNA (rRNA) gene, rather than by nuclear DNA. This makes it a “mitochondrial-derived peptide” (MDP). It is a 16-amino acid peptide that plays a crucial role in cellular metabolism, particularly in skeletal muscle, where it influences metabolic flexibility and energy homeostasis. Its discovery has opened new avenues in understanding how mitochondria, beyond their role in ATP production, also function as signaling organelles.

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Description

Quick Facts

MOTS-c primarily acts by influencing metabolic pathways, especially those related to glucose and fatty acid metabolism. It has been shown to enhance insulin sensitivity in skeletal muscle, promote glucose uptake, and potentially activate the AMPK (AMP-activated protein kinase) pathway. Activation of AMPK is critical for regulating cellular energy balance, stimulating fatty acid oxidation, and inhibiting glucose production. By affecting these core metabolic processes, MOTS-c helps maintain cellular energy homeostasis and contributes to metabolic health. Its actions appear to be independent of classic growth hormone/IGF-1 axes.

 

  • Metabolic Health & Disorders: Extensive research focuses on its potential role in addressing insulin resistance, type 2 diabetes, obesity, and non-alcoholic fatty liver disease (NAFLD) by improving glucose utilization and fatty acid metabolism.
  • Skeletal Muscle Metabolism: Investigated for its direct impact on muscle cells, promoting glucose uptake and potentially enhancing exercise capacity and resilience.
  • Mitochondrial Function: Studies explore how MOTS-c influences mitochondrial biogenesis, dynamics, and overall health, highlighting the broader signaling roles of mitochondria.
  • Aging & Longevity: Due to its influence on metabolic pathways that are often dysregulated with age, MOTS-c is a subject of interest in healthy aging research and the development of interventions against age-related metabolic decline.
  • Cardiovascular Health: Emerging research suggests potential benefits related to endothelial function and metabolic health of the cardiovascular system.

 

Why Choose Peptide Chains for MOTS-C?

Peptide Chains provides high-purity MOTS-c in bulk API quantities, essential for rigorous and cutting-edge metabolic research. Our MOTS-c is supplied in a stable, lyophilized format, ensuring optimal integrity and ease of handling for precise experimental protocols. We are committed to stringent quality control, including comprehensive analytical testing, to guarantee the exceptional purity, potency, and batch-to-batch consistency required for reliable and reproducible results in studies focused on metabolic regulation, mitochondrial biology, and healthy aging interventions.

Additional information

Weight 0.05 lbs
Dimensions 10 × 15 × 5 in
Size

100g, 500g, 1kg

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At Peptide Chains, we specialize in providing high-quality bulk Active Pharmaceutical Ingredients (APIs) and lyophilized compounds. We are dedicated to supplying the essential raw materials critical for innovation and development within the pharmaceutical, biotechnology, and compounding industries.

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