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NAD+
NAD+

NAD+

NAD+ (Nicotinamide Adenine Dinucleotide) is a fundamental coenzyme found in all living cells, playing an indispensable role in cellular metabolism and energy production. It exists in two forms: NAD+ (the oxidized form) and NADH (the reduced form), which continuously cycle between each other as they facilitate critical biochemical reactions. As a central player in redox reactions, NAD+ is essential for converting nutrients into energy, functioning as a vital electron acceptor in metabolic pathways such as glycolysis, the Krebs cycle, and oxidative phosphorylation. Its ubiquitous presence and involvement in thousands of enzymatic processes underscore its importance for virtually all biological functions.

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Description

Quick Facts

NAD+ functions as a coenzyme, acting as a shuttle for electrons in numerous oxidation-reduction reactions, which are fundamental to cellular respiration and ATP synthesis. Beyond its metabolic role, NAD+ is also a crucial substrate for several non-redox enzymes involved in critical cellular processes. These include:

 

  • Sirtuins: A family of proteins that regulate cellular health, DNA repair, inflammation, and aging. Sirtuins are NAD+-dependent.
  • PARPs (Poly-ADP-ribose polymerases): Enzymes involved in DNA repair and genome integrity.
  • CD38/CD157: Enzymes involved in calcium signaling and NAD+ metabolism. By serving as a substrate for these enzymes, NAD+ directly influences epigenetic regulation, DNA repair mechanisms, cellular stress responses, and the regulation of circadian rhythms, profoundly impacting cellular longevity and resilience.

 

Key Research Areas & Applications:

  • Aging & Longevity: NAD+ levels naturally decline with age, and research is extensively exploring the link between NAD+ depletion and age-related decline, as well as the potential of NAD+ precursors (like NMN and NR) to boost NAD+ levels and support healthy aging.
  • Metabolic Health: Investigated for its role in metabolic disorders such as type 2 diabetes, obesity, and fatty liver disease, by improving mitochondrial function and insulin sensitivity.
  • Neuroprotection: Studies explore its potential in neurodegenerative diseases like Alzheimer’s and Parkinson’s, given its role in neuronal energy metabolism and DNA repair.
  • Cardiovascular Health: Research into its impact on vascular function, endothelial health, and overall cardiovascular resilience.
  • Mitochondrial Function: Fundamental to studies on mitochondrial biogenesis, efficiency, and combating mitochondrial dysfunction, which underlies many chronic diseases.

 

Why Choose Peptide Chains for NAD+?

Peptide Chains provides high-purity NAD+ in bulk API quantities, essential for comprehensive and advanced biochemical and biomedical research. Our NAD+ is meticulously synthesized and supplied in a stable, lyophilized format, ensuring optimal integrity, purity, and ease of handling for your precise experimental protocols. We maintain stringent quality control standards, including detailed analytical verification, to guarantee the exceptional purity, potency, and batch-to-batch consistency that is critical for reliable and reproducible results in studies focused on cellular metabolism, aging, neuroprotection, and overall cellular health.

Additional information

Weight 0.05 lbs
Dimensions 10 × 15 × 5 in
Size

100g, 500g, 1kg

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At Peptide Chains, we specialize in providing high-quality bulk Active Pharmaceutical Ingredients (APIs) and lyophilized compounds. We are dedicated to supplying the essential raw materials critical for innovation and development within the pharmaceutical, biotechnology, and compounding industries.

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