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Pentadeca-Arginate-(PDA)
Pentadeca-Arginate-(PDA)

Pentadeca-Arginate-(PDA)

Pentadeca-Arginate (PDA) is a synthetic peptide characterized by its highly polycationic nature, consisting of 15 arginine residues (Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg or (Arg)15). This extensive repetition of positively charged arginine residues is a key feature that gives PDA its distinct biophysical properties, particularly its ability to interact strongly with negatively charged molecules and cell membranes. Peptides rich in basic amino acids like arginine are often explored for their roles as cell-penetrating peptides (CPPs) or for their direct effects on cellular processes influenced by charge interactions.

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Description

Quick Facts

The primary mechanism of action for Pentadeca-Arginate is largely attributed to its strong positive charge, which facilitates interactions with negatively charged components of cell membranes and nucleic acids. This property allows PDA to:

 

  • Cell Penetration/Transduction: Act as a cell-penetrating peptide, enabling the non-covalent delivery of various cargo molecules (e.g., small molecules, peptides, proteins, nucleic acids like DNA/RNA) across cell membranes, potentially without causing significant membrane disruption. This makes it a valuable tool in drug delivery and gene therapy research.
  • Direct Cellular Interactions: Its polycationic nature may allow for direct interactions with cellular components, potentially modulating intracellular signaling pathways or enzyme activities.
  • Antimicrobial Properties (Hypothesized): Some arginine-rich peptides exhibit antimicrobial activity by disrupting bacterial membranes, and this is a potential area of exploration for PDA due to its structural characteristics.
  • Modulation of Protein-Nucleic Acid Interactions: The positively charged arginine residues can interact with negatively charged phosphate backbones of DNA and RNA, potentially influencing gene expression or complex formation.
  • Drug Delivery Systems: Primarily investigated as a highly efficient carrier for delivering therapeutic agents, including large biomolecules, into various cell types and tissues, enhancing their bioavailability and intracellular accumulation.
  • Gene Therapy: Explored for its potential in delivering genetic material (plasmids, siRNAs) into cells for research or therapeutic purposes.
  • Bioimaging: Used as a tool to facilitate the cellular uptake of imaging probes for diagnostic or research applications.
  • Antimicrobial Research: Preliminary or exploratory studies into its potential as an antimicrobial agent against various pathogens.
  • Cellular Permeability Studies: A valuable research tool for understanding mechanisms of cellular uptake and membrane transport.
Why Choose Peptide Chains for Pentadeca-Arginate (PDA)?

Peptide Chains provides high-purity Pentadeca-Arginate in bulk API quantities, essential for cutting-edge research in drug delivery, gene therapy, and cellular biology. Our PDA is meticulously synthesized and supplied in a stable, lyophilized format, ensuring optimal integrity, purity (typically ≥97%), and ease of reconstitution for your precise experimental protocols. We are committed to stringent quality control, including comprehensive analytical testing, to guarantee the exceptional purity, consistent charge profile, and batch-to-batch reliability that is critical for reproducible results in studies focused on enhancing cellular uptake, exploring novel therapeutic delivery platforms, and understanding polycationic peptide interactions.

Additional information

Weight 0.05 lbs
Dimensions 10 × 15 × 5 in
Size

100g, 500g, 1kg

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At Peptide Chains, we specialize in providing high-quality bulk Active Pharmaceutical Ingredients (APIs) and lyophilized compounds. We are dedicated to supplying the essential raw materials critical for innovation and development within the pharmaceutical, biotechnology, and compounding industries.

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