Name: SS-31
SKU: 134
Availability: InStock

SS-31

SS-31, chemically known as D-Arg-Dmt-Lys-Phe-NH2 (where Dmt is dimethyltyrosine), is a novel and highly targeted mitochondrial-targeted peptide. It belongs to a class of peptides designed to selectively accumulate in the inner mitochondrial membrane, precisely where oxidative phosphorylation (the primary process of ATP synthesis) occurs. This specific targeting is critical to its therapeutic potential, as mitochondrial dysfunction is a hallmark of numerous age-related diseases and chronic conditions. SS-31 is a relatively small and highly permeable peptide, allowing it to efficiently traverse cellular membranes to reach its site of action within the mitochondria.

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SKU: 134 Category:Bulk API

Description
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Quick Facts

SS-31 exerts its primary effects by directly interacting with cardiolipin, a unique phospholipid found almost exclusively in the inner mitochondrial membrane. This interaction helps stabilize cardiolipin, which is crucial for maintaining the structural integrity and optimal function of the electron transport chain (ETC) complexes. By preventing cardiolipin oxidation and maintaining its proper conformation, SS-31 can:

Enhance Mitochondrial Bioenergetics: Improve the efficiency of electron transport and ATP production, thereby optimizing cellular energy supply.
Reduce Reactive Oxygen Species (ROS): Minimize the leakage of electrons from the ETC, consequently reducing the generation of harmful reactive oxygen species (free radicals) that contribute to oxidative stress and cellular damage.
Preserve Mitochondrial Integrity: Protect mitochondria from swelling and rupture, which are indicative of severe mitochondrial dysfunction and can trigger apoptosis (programmed cell death).
Restore Mitochondrial Dynamics: Support healthy mitochondrial fission and fusion processes, which are essential for quality control and cellular adaptation.

Mitochondrial Dysfunction-Related Diseases: Extensive research in conditions where mitochondrial impairment plays a central role, including:
- Ischemia-Reperfusion Injury: Protecting tissues (e.g., heart, kidney, brain) from damage after blood flow is restored following a period of ischemia.
- Neurodegenerative Diseases: Exploring its potential in conditions like Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease by mitigating neuronal mitochondrial dysfunction.
- Age-Related Diseases: Investigating its role in healthy aging, sarcopenia, and other conditions associated with age-related decline in mitochondrial function.
- Kidney Disease: Studies on its renoprotective effects, particularly in chronic kidney disease and acute kidney injury.
- Ophthalmic Diseases: Research into its potential in conditions like age-related macular degeneration and diabetic retinopathy.
Metabolic Disorders: Exploring its impact on metabolic efficiency and energy expenditure in various cellular contexts.
Inflammation and Oxidative Stress: Investigating its direct anti-inflammatory and antioxidant properties within the cellular environment.

Why Choose Peptide Chains for SS-31 (Elamipretide)?

Peptide Chains provides high-purity SS-31 (Elamipretide) in bulk API quantities, essential for cutting-edge research and pharmaceutical development targeting mitochondrial health. Our SS-31 is meticulously synthesized and supplied in a stable, lyophilized format, ensuring optimal integrity, purity (typically ≥98%), and ease of reconstitution for your precise experimental protocols. We are committed to stringent quality control, including comprehensive analytical testing, to guarantee the exceptional purity, potency, and batch-to-batch consistency that is critical for reliable and reproducible results in studies focused on mitochondrial bioenergetics, cellular protection, and the treatment of complex diseases linked to mitochondrial dysfunction.