Melanotan-II

Melanotan-II (MT-II) is a synthetic cyclic heptapeptide analog of the naturally occurring alpha-melanocyte-stimulating hormone (α-MSH). α-MSH is an endogenous melanocortin peptide that plays a central role in various physiological processes, including skin pigmentation, appetite regulation, and sexual function. MT-II was developed to be more potent and stable than its natural counterpart, making it a powerful tool for research into melanocortin receptor system. It is designed to selectively activate specific melanocortin receptors (MCRs) found throughout the body.

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SKU: 172 Category:Bulk API

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Quick Facts

Melanotan-II primarily exerts its effects by activating melanocortin receptors, particularly MC1R, MC3R, and MC4R.

MC1R Activation (Skin Pigmentation): Activation of the MC1R, located on melanocytes (the pigment-producing cells in the skin), stimulates the production of eumelanin, a dark pigment that contributes to skin tanning and provides photoprotection against UV radiation. This is the mechanism underlying its well-known effect on skin pigmentation.
MC3R & MC4R Activation (Appetite and Sexual Function): Activation of MC3R and MC4R, which are abundantly expressed in the central nervous system (especially the hypothalamus), contributes to its effects on appetite suppression and sexual function. The melanocortin system in the brain is a critical regulator of energy homeostasis and sexual arousal.

Skin Pigmentation Research: Extensively studied for its role in inducing melanogenesis and its potential for photoprotection in individuals with certain skin conditions (e.g., erythropoietic protoporphyria).
Obesity and Appetite Regulation: Investigated for its anorexic effects through the activation of hypothalamic melanocortin pathways, leading to reduced food intake and potential weight loss in preclinical models.
Sexual Dysfunction: Explored for its potential to induce erections in males and improve sexual function in both males and females, via central nervous system pathways.
Melanocortin System Research: Used as a pharmacological tool to further elucidate the complex roles of various melanocortin receptors in diverse physiological processes beyond pigmentation, including inflammation, pain, and neurological functions.

Why Choose Peptide Chains for Melanotan-II?

Peptide Chains provides high-purity Melanotan-II in bulk API quantities, essential for rigorous scientific research and development focusing on melanocortin receptor pharmacology. Our MT-II is meticulously synthesized and supplied in a stable, lyophilized format, ensuring optimal integrity, purity (typically ≥98%), and ease of reconstitution for your precise experimental protocols. We are committed to stringent quality control, including comprehensive analytical testing, to guarantee the exceptional purity, potency, and batch-to-batch consistency that is critical for reliable and reproducible results in studies focused on skin pigmentation, appetite regulation, sexual function, and the intricate biology of the melanocortin system.